Discovery of biological networks from diverse functional genomic data

  title={Discovery of biological networks from diverse functional genomic data},
  author={Chad L. Myers and D. J. Robson and Adam Wible and Matthew A. Hibbs and Camelia Chiriac and Chandra L. Theesfeld and Kara Dolinski and Olga G. Troyanskaya},
  journal={Genome Biology},
  pages={R114 - R114}
We have developed a general probabilistic system for query-based discovery of pathway-specific networks through integration of diverse genome-wide data. This framework was validated by accurately recovering known networks for 31 biological processes in Saccharomyces cerevisiae and experimentally verifying predictions for the process of chromosomal segregation. Our system, bioPIXIE, a public, comprehensive system for integration, analysis, and visualization of biological network predictions for… CONTINUE READING
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