Discovery of bicyclo[3,3,1]non-2-ene as a novel skeleton for HIF-1 inhibitors.

@article{Ueda2018DiscoveryOB,
  title={Discovery of bicyclo[3,3,1]non-2-ene as a novel skeleton for HIF-1 inhibitors.},
  author={Hiroki R Ueda and Atsushi Yoshimori and Hiroyuki Nakamura},
  journal={Bioorganic & medicinal chemistry},
  year={2018},
  volume={26 12},
  pages={
          3345-3351
        }
}
Bicyclo[3,3,1]non-2-ene was used as a novel three-dimensional skeleton for the design and synthesis of hypoxia-inducible factor (HIF)-1 inhibitors. Among the compounds synthesized, compound 4b was found to be a potent inhibitor of HIF-1α protein accumulation under hypoxia and inhibited HIF-1α transcriptional activity in HeLa (human cervical carcinoma) cells… CONTINUE READING