Discovery of biclonal origin and a novel oncogene SLC12A5 in colon cancer by single-cell sequencing

@article{Yu2014DiscoveryOB,
  title={Discovery of biclonal origin and a novel oncogene SLC12A5 in colon cancer by single-cell sequencing},
  author={Chang Yu and Jun Yu and Xiaotian Yao and William Kk Wu and Youyong Lu and Senwei Tang and Xiangchun Li and Li Bao and Xiaoxing Li and Yong Hou and Renhua Wu and Min Jian and Ruoyan Chen and Fan Zhang and Lixia Xu and Fan Fan and Jun He and Qiaoyi Liang and Hongyi Wang and Xueda Hu and Minghui He and Xiang Zhang and Hancheng Zheng and Qibin Li and Hanjie Wu and Yan Chen and Xu Yang and Shida Zhu and Xun Xu and Huanming Yang and Jian Wang and Xiuqing Zhang and Joseph J. Y. Sung and Yingrui Li and Jun Wang},
  journal={Cell Research},
  year={2014},
  volume={24},
  pages={701-712}
}
Single-cell sequencing is a powerful tool for delineating clonal relationship and identifying key driver genes for personalized cancer management. Here we performed single-cell sequencing analysis of a case of colon cancer. Population genetics analyses identified two independent clones in tumor cell population. The major tumor clone harbored APC and TP53 mutations as early oncogenic events, whereas the minor clone contained preponderant CDC27 and PABPC1 mutations. The absence of APC and TP53… CONTINUE READING