Discovery of betulinic acid as a selective inhibitor of human melanoma that functions by induction of apoptosis

@article{Pisha1995DiscoveryOB,
  title={Discovery of betulinic acid as a selective inhibitor of human melanoma that functions by induction of apoptosis},
  author={E. Pisha and H. Chai and I. Lee and T. E. Chagwedera and N. Farnsworth and G. Cordell and C. Beecher and H. Fong and A. Kinghorn and D. Brown and M. Wani and M. Wall and T. Hieken and T. D. Gupta and J. Pezzuto},
  journal={Nature Medicine},
  year={1995},
  volume={1},
  pages={1046-1051}
}
  • E. Pisha, H. Chai, +12 authors J. Pezzuto
  • Published 1995
  • Biology, Medicine
  • Nature Medicine
  • As a result of bioassay–guided fractionation, betulinic acid, a pentacyclic triterpene, was identified as a melanoma–specific cytotoxic agent. In follow–up studies conducted with athymic mice carrying human melanomas, tumour growth was completely inhibited without toxicity. As judged by a variety of cellular responses, antitumour activity was mediated by the induction of apoptosis. Betulinic acid is inexpensive and available in abundant supply from common natural sources, notably the bark of… CONTINUE READING
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