Discovery of betulinic acid as a selective inhibitor of human melanoma that functions by induction of apoptosis
@article{Pisha1995DiscoveryOB, title={Discovery of betulinic acid as a selective inhibitor of human melanoma that functions by induction of apoptosis}, author={E. Pisha and H. Chai and I. Lee and T. E. Chagwedera and N. Farnsworth and G. Cordell and C. Beecher and H. Fong and A. Kinghorn and D. Brown and M. Wani and M. Wall and T. Hieken and T. D. Gupta and J. Pezzuto}, journal={Nature Medicine}, year={1995}, volume={1}, pages={1046-1051} }
As a result of bioassay–guided fractionation, betulinic acid, a pentacyclic triterpene, was identified as a melanoma–specific cytotoxic agent. In follow–up studies conducted with athymic mice carrying human melanomas, tumour growth was completely inhibited without toxicity. As judged by a variety of cellular responses, antitumour activity was mediated by the induction of apoptosis. Betulinic acid is inexpensive and available in abundant supply from common natural sources, notably the bark of… CONTINUE READING
Topics from this paper
713 Citations
Betulinic Acid for Cancer Treatment and Prevention
- Medicine
- International journal of molecular sciences
- 2008
- 230
- PDF
Lupane Triterpenoids—Betulin and Betulinic acid derivatives induce apoptosis in tumor cells
- Biology, Medicine
- Investigational New Drugs
- 2009
- 50
- PDF
Targeting mitochondrial apoptosis by betulinic acid in human cancers.
- Biology, Medicine
- Drug discovery today
- 2009
- 148
Development of C-20 modified betulinic acid derivatives as antitumor agents.
- Chemistry, Medicine
- Bioorganic & medicinal chemistry letters
- 2001
- 65
Betulinic acid, a natural compound with potent anticancer effects
- Medicine, Biology
- Anti-cancer drugs
- 2010
- 149
Synthesis of betulinic acid derivatives with activity against human melanoma.
- Chemistry, Medicine
- Bioorganic & medicinal chemistry letters
- 1998
- 112
Carbamate derivatives of betulinic acid and betulin with selective cytotoxic activity.
- Chemistry, Medicine
- Bioorganic & medicinal chemistry letters
- 2010
- 47
Betulinic acid: a natural product with anticancer activity.
- Biology, Medicine
- Molecular nutrition & food research
- 2009
- 107
Betulinic acid inhibits prostate cancer growth through inhibition of specificity protein transcription factors.
- Biology, Medicine
- Cancer research
- 2007
- 264
- Highly Influenced
- PDF
Cytotoxic betulin-derived hydroxypropargylamines trigger apoptosis.
- Chemistry, Medicine
- Bioorganic & medicinal chemistry
- 2013
- 24
References
SHOWING 1-10 OF 27 REFERENCES
Tumor inhibitors. I. Preliminary investigation of antitumor activity of Sarracenia flava.
- Biology, Medicine
- Journal of pharmaceutical sciences
- 1974
- 39
Anti-AIDS agents, 11. Betulinic acid and platanic acid as anti-HIV principles from Syzigium claviflorum, and the anti-HIV activity of structurally related triterpenoids.
- Biology, Medicine
- Journal of natural products
- 1994
- 371
Tumor inhibitory agents from Vauquelinia corymbosa (Rosaceae).
- Chemistry, Medicine
- Journal of pharmaceutical sciences
- 1976
- 37
Tumor-inhibitory agent from Hyptis emoryi (Labiatae).
- Chemistry, Medicine
- Journal of pharmaceutical sciences
- 1972
- 34
Apoptosis in the genesis and prevention of cancer.
- Biology, Medicine
- Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology
- 1992
- 105
Cytotoxic and antimalarial alkaloids from the tubers of Stephania pierrei.
- Biology, Medicine
- Journal of natural products
- 1993
- 96
Sequential chemoimmunotherapy in the treatment of metastatic melanoma.
- Medicine
- Journal of clinical oncology : official journal of the American Society of Clinical Oncology
- 1992
- 236
Tamoxifen: is it useful in the treatment of patients with metastatic melanoma?
- Medicine
- Journal of clinical oncology : official journal of the American Society of Clinical Oncology
- 1994
- 44