Discovery of azetidine based ene-amides as potent bacterial enoyl ACP reductase (FabI) inhibitors.

@article{Takhi2014DiscoveryOA,
  title={Discovery of azetidine based ene-amides as potent bacterial enoyl ACP reductase (FabI) inhibitors.},
  author={Mohamed Takhi and Kandepu Sreenivas and Chandrashekar K Reddy and Mahadari Munikumar and Kolakota Praveena and Pabolu Sudheer and Bandaru N V M Rao and Gollamudi Ramakanth and Jampala Sivaranjani and Shardaprasad Mulik and Yeruva R Reddy and Krishnamurthy Narasimha Rao and Rentala Pallavi and Anirudha Lakshminarasimhan and Sunil K. Panigrahi and Thomas Antony and Iskandar Abdullah and Yean Kee Lee and Murali Ramachandra and Rohana Yusof and Noorsaadah Abdul Rahman and Hosahalli S Subramanya},
  journal={European journal of medicinal chemistry},
  year={2014},
  volume={84},
  pages={382-94}
}
A novel and potent series of ene-amides featuring azetidines has been developed as FabI inhibitors active against drug resistant Gram-positive pathogens particularly staphylococcal organisms. Most of the compounds from the series possessed excellent biochemical inhibition of Staphylococcus aureus FabI enzyme and whole cell activity against clinically… CONTINUE READING