Discovery of an androgen receptor modulator pharmacophore based on 2-quinolinones.

@article{Oeveren2007DiscoveryOA,
  title={Discovery of an androgen receptor modulator pharmacophore based on 2-quinolinones.},
  author={Arjan van Oeveren and Barbara A Pio and Christopher M Tegley and Robert I Higuchi and Min Wu and Todd K. Jones and Keith B. Marschke and Andr{\'e}s Negro-Vilar and Lin Zhi},
  journal={Bioorganic & medicinal chemistry letters},
  year={2007},
  volume={17 6},
  pages={1523-6}
}
A series of alkylamino-2-quinolinone compounds (3) was discovered as androgen receptor modulators based on an early linear tricyclic quinoline pharmacophore (1). The series demonstrated selective high binding affinity to androgen receptor and potent receptor modulating activities in the cotransfection assays.