Discovery of amino-acetonitrile derivatives, a new class of synthetic anthelmintic compounds.

@article{Ducray2008DiscoveryOA,
  title={Discovery of amino-acetonitrile derivatives, a new class of synthetic anthelmintic compounds.},
  author={Pierre Ducray and No{\"e}lle Gauvry and François Pautrat and Thomas Goebel and Joerg Fruechtel and Yves Desaules and Sandra Schorderet Weber and Jacques Bouvier and Trixie Wagner and Olivier Froelich and Ronald Kaminsky},
  journal={Bioorganic & medicinal chemistry letters},
  year={2008},
  volume={18 9},
  pages={2935-8}
}
A new series of amino-acetonitrile derivatives (AAD) have been discovered that exhibit high anthelmintic activity against parasitic nematode species such as Haemonchus contortus and Trichostrongylus colubriformis. Significantly, these compounds also demonstrate activity against nematode strains resistant to the currently available broad-spectrum anthelmintics. The discovery, synthesis, structure-activity relationship and biological results are presented. 

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