Discovery of adrenomedullin in rat ischemic cortex and evidence for its role in exacerbating focal brain ischemic damage.

@article{Wang1995DiscoveryOA,
  title={Discovery of adrenomedullin in rat ischemic cortex and evidence for its role in exacerbating focal brain ischemic damage.},
  author={Xin Wang and Tian-li Yue and Frank Barone and Ray F White and Robert K. Clark and Robert N. Willette and Anthony C. Sulpizio and Nambi V. Aiyar and Robert R. Ruffolo and Giora G Z Feuerstein},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1995},
  volume={92 25},
  pages={11480-4}
}
Focal brain ischemia is the most common event leading to stroke in humans. To understand the molecular mechanisms associated with brain ischemia, we applied the technique of mRNA differential display and isolated a gene that encodes a recently discovered peptide, adrenomedullin (AM), which is a member of the calcitonin gene-related peptide (CGRP) family. Using the rat focal stroke model of middle cerebral artery occlusion (MCAO), we determined that AM mRNA expression was significantly increased… CONTINUE READING

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