Discovery of a spermatogenesis stage-specific ornithine decarboxylase antizyme: antizyme 3.

@article{Ivanov2000DiscoveryOA,
  title={Discovery of a spermatogenesis stage-specific ornithine decarboxylase antizyme: antizyme 3.},
  author={Ivaylo P. Ivanov and Andreas Rohrwasser and Daniel A. Terreros and Raymond F. Gesteland and John F. Atkins},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2000},
  volume={97 9},
  pages={4808-13}
}
Previous studies with mice overproducing ornithine decarboxylase have demonstrated the importance of polyamine homeostasis for normal mammalian spermatogenesis. The present study introduces a likely key player in the maintenance of proper polyamine homeostasis during spermatogenesis. Antizyme 3 is a paralog of mammalian ornithine decarboxylase antizymes. Like its previously described counterparts, antizymes 1 and 2, it inhibits ornithine decarboxylase, which catalyzes the synthesis of… CONTINUE READING
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Ornithine Decarboxylase: Biology, Enzymology, and Molecular Genetics, ed

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