Discovery of a series of N-(5-(quinolin-6-yl)pyridin-3-yl)benzenesulfonamides as PI3K/mTOR dual inhibitors.

@article{Zhang2017DiscoveryOA,
  title={Discovery of a series of N-(5-(quinolin-6-yl)pyridin-3-yl)benzenesulfonamides as PI3K/mTOR dual inhibitors.},
  author={Jiankang Zhang and Xiaoqing Lv and Xiaodong Ma and Yong-zhou Hu},
  journal={European journal of medicinal chemistry},
  year={2017},
  volume={127},
  pages={509-520}
}
Recently, the phosphoinositide 3-kinase (PI3K) and mammalian target of rapamycin (mTOR) have been considered as promising targets for the treatment of cancer. Herein, we synthesized a series of N-(5-(quinolin-6-yl)pyridin-3-yl)benzenesulfonamides as novel PI3K/mTOR dual inhibitors for cancer therapy. In the biological evaluation, compound 17e was identified… CONTINUE READING