Discovery of a rich gene pool of bat SARS-related coronaviruses provides new insights into the origin of SARS coronavirus

@article{Hu2017DiscoveryOA,
  title={Discovery of a rich gene pool of bat SARS-related coronaviruses provides new insights into the origin of SARS coronavirus},
  author={Ben Hu and Leiping Zeng and Xīngl{\'o}u Y{\'a}ng and Xingyi Ge and Wei Zhang and Bei Li and Jia-zheng Xie and Xurui Shen and Yunzhi Zhang and Ning Wang and Dongsheng Luo and Xiao-Shuang Zheng and Meiniang Wang and Peter Daszak and Lin‐Fa Wang and Jie Cui and Zh{\`e}ngl{\`i} Sh{\'i}},
  journal={PLoS Pathogens},
  year={2017},
  volume={13}
}
A large number of SARS-related coronaviruses (SARSr-CoV) have been detected in horseshoe bats since 2005 in different areas of China. However, these bat SARSr-CoVs show sequence differences from SARS coronavirus (SARS-CoV) in different genes (S, ORF8, ORF3, etc) and are considered unlikely to represent the direct progenitor of SARS-CoV. Herein, we report the findings of our 5-year surveillance of SARSr-CoVs in a cave inhabited by multiple species of horseshoe bats in Yunnan Province, China. The… 
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Horizontal gene transfer and recombination analysis of SARS-CoV-2 genes helps discover its close relatives and shed light on its origin
TLDR
The results of the horizontal gene transfer and recombination analysis suggest that SARS-CoV-2 could not only be a chimera virus resulting from recombination of the bat RaTG13 and Guangdong pangolin coronaviruses but also a close relative of theBat CoV ZC45 and ZXC21 strains.
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The subtle sequence similarities imply that Orf8 has the same immunoglobulin-like fold as Orf7a, confirmed by structure determination, and characterize the subgroups of this superfamily and demonstrate the highly idiosyncratic divergence patterns during the evolution of the virus.
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