Discovery of a receptor related to the galanin receptors.

  title={Discovery of a receptor related to the galanin receptors.},
  author={Dennis K.-Y. Lee and T -S. Nguyen and G. Patrick O'Neill and Regina Cheng and Yuan Liu and Andrew D. Howard and Nathalie Coulombe and Carina P. Tan and A T Tang-Nguyen and Susan R. George and Brian F O'dowd},
  journal={FEBS letters},
  volume={446 1},
We report the isolation of a cDNA clone named GPR54, which encodes a novel G protein-coupled receptor (GPCR). A PCR search of rat brain cDNA retrieved a clone partially encoding a GPCR. In a library screening this clone was used to isolate a cDNA with an open reading frame (ORF) encoding a receptor of 396 amino acids long which shared significant identities in the transmembrane regions with rat galanin receptors GalR1 (45%), GalR3 (45%) and GalR2 (44%). Northern blot and in situ hybridization… CONTINUE READING
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