Discovery of a potent and selective aurora kinase inhibitor.

  title={Discovery of a potent and selective aurora kinase inhibitor.},
  author={Johan D. Oslob and Michael J. Romanowski and Darin A Allen and Subramanian Baskaran and Minna Bui and Robert A. Elling and W. Michael Flanagan and Amy D Fung and Emily J. Hanan and Shannon Harris and Stacey A Heumann and Ute R Hoch and Jeffrey W. Jacobs and Joni W. Lam and Chris E Lawrence and Robert S. McDowell and Michelle A. Nannini and Wang Jin Shen and Jeffrey A. Silverman and Michelle M Sopko and Bradley T Tangonan and Juli N. Teague and Josh C Yoburn and Chul H Yu and Ming Zhong and Kristin M. Zimmerman and Tom O'Brien and Willard Lew},
  journal={Bioorganic & medicinal chemistry letters},
  volume={18 17},
This communication describes the discovery of a novel series of Aurora kinase inhibitors. Key SAR and critical binding elements are discussed. Some of the more advanced analogues potently inhibit cellular proliferation and induce phenotypes consistent with Aurora kinase inhibition. In particular, compound 21 (SNS-314) is a potent and selective Aurora kinase inhibitor that exhibits significant activity in pre-clinical in vivo tumor models. 

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