Discovery of a β-d-2'-deoxy-2'-α-fluoro-2'-β-C-methyluridine nucleotide prodrug (PSI-7977) for the treatment of hepatitis C virus.

@article{Sofia2010DiscoveryOA,
  title={Discovery of a β-d-2'-deoxy-2'-α-fluoro-2'-β-C-methyluridine nucleotide prodrug (PSI-7977) for the treatment of hepatitis C virus.},
  author={Michael J. Sofia and Donghui Bao and Wonsuk Chang and Jinfa Du and Dhanapalan Nagarathnam and Suguna Rachakonda and Prudhvinath Reddy and Bruce Ross and Peiyuan Wang and Hai-Ren Zhang and Shalini Bansal and Christine L Espiritu and Meg Keilman and Angela Lam and Holly M. Micolochick Steuer and Congrong Niu and Michael J. Otto and Phillip A. Furman},
  journal={Journal of medicinal chemistry},
  year={2010},
  volume={53 19},
  pages={
          7202-18
        }
}
Hepatitis C virus (HCV) is a global health problem requiring novel approaches for effective treatment of this disease. The HCV NS5B polymerase has been demonstrated to be a viable target for the development of HCV therapies. β-d-2'-Deoxy-2'-α-fluoro-2'-β-C-methyl nucleosides are selective inhibitors of the HCV NS5B polymerase and have demonstrated potent activity in the clinic. Phosphoramidate prodrugs of the 5'-phosphate derivative of the β-d-2'-deoxy-2'-α-fluoro-2'-β-C-methyluridine… CONTINUE READING
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