Discovery of a novel protein tyrosine phosphatase-1B inhibitor, KR61639: potential development as an antihyperglycemic agent.

@article{Cheon2004DiscoveryOA,
  title={Discovery of a novel protein tyrosine phosphatase-1B inhibitor, KR61639: potential development as an antihyperglycemic agent.},
  author={H. Cheon and Sun-Mee Kim and Sung-Don Yang and J. Ha and Joong-Kwon Choi},
  journal={European journal of pharmacology},
  year={2004},
  volume={485 1-3},
  pages={
          333-9
        }
}
  • H. Cheon, Sun-Mee Kim, +2 authors Joong-Kwon Choi
  • Published 2004
  • Medicine, Chemistry
  • European journal of pharmacology
  • Protein tyrosine phosphatase-1B (PTP-1B), a negative regulator of insulin signaling, may be an attractive therapeutic target for type 2 diabetes mellitus. High throughput screening (HTS) for PTP-1B inhibitors using compounds from the Korea Chemical Bank identified several hits (active compounds). Among them, a hit with 1,2-naphthoquinone scaffold was chosen for lead development. KR61639, [4-[1-(1H-indol-3-yl)-3,4-dioxo-3,4-dihydro-naphthalen-2-ylmethyl]-phenoxy]-acetic acid tert-butyl ester… CONTINUE READING
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