Discovery of a novel natural killer cell line with distinct immunostimulatory and proliferative potential as an alternative platform for cancer immunotherapy

@inproceedings{Yang2019DiscoveryOA,
  title={Discovery of a novel natural killer cell line with distinct immunostimulatory and proliferative potential as an alternative platform for cancer immunotherapy},
  author={Hyun Gul Yang and Moon Cheol Kang and Tae Yoon Kim and Injung Hwang and Hyun Tak Jin and Young Chul Sung and Ki-Seong Eom and Sae Won Kim},
  booktitle={Journal for immunotherapy of cancer},
  year={2019}
}
BackgroundHuman natural killer (NK) cell lines serve as an attractive source for adoptive immunotherapy, but NK-92 remains the only cell line being assessed in the clinic. Here, we established a novel NK cell line, NK101, from a patient with extra-nodal natural killer/T-cell lymphoma and examined its phenotypic, genomic and functional characteristics.MethodsSingle cell suspensions from lymphoma tissue were expanded with anti-NKp46/anti-CD2-coated beads in the presence of IL-2. A continuously… CONTINUE READING
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