Discovery of a novel lead structure for anti-malarials.

@article{Wiesner2001DiscoveryOA,
  title={Discovery of a novel lead structure for anti-malarials.},
  author={Jochen Wiesner and Pia Wissner and Hans Martin Dahse and Hassan Jomaa and Martin Schlitzer},
  journal={Bioorganic \& medicinal chemistry},
  year={2001},
  volume={9 3},
  pages={
          785-92
        }
}
From a library of 61 compounds available from former studies 2,5-bis-acylaminobenzophenone 7p was identified as a lead structure for a novel class of anti-malaria agents active against multi-resistant Plasmodium falciparum strain Dd2. Some structural modifications of this initial lead demonstrated the potential for further improvement of the anti-plasmodial activity of this novel class of anti-malarials. 
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