Discovery of a novel iflavirus sequence in the eastern paralysis tick Ixodes holocyclus

@article{OBrien2018DiscoveryOA,
  title={Discovery of a novel iflavirus sequence in the eastern paralysis tick Ixodes holocyclus},
  author={Caitlin A O'Brien and Sonja Hall-Mendelin and Jody Hobson-Peters and Georgia Deliyannis and Andy Allen and Ala E. Lew-Tabor and Manuel Rodr{\'i}guez-Valle and D Barker and Stephen C. Barker and Roy A. Hall},
  journal={Archives of Virology},
  year={2018},
  volume={163},
  pages={2451-2457}
}
Ixodes holocyclus, the eastern paralysis tick, is a significant parasite in Australia in terms of animal and human health. However, very little is known about its virome. In this study, next-generation sequencing of I. holocyclus salivary glands yielded a full-length genome sequence which phylogenetically groups with viruses classified in the Iflaviridae family and shares 45% amino acid similarity with its closest relative Bole hyalomma asiaticum virus 1. The sequence of this virus… Expand
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References

SHOWING 1-10 OF 40 REFERENCES
Exploring the transcriptomic data of the Australian paralysis tick, Ixodes holocyclus
TLDR
Comparisons of contig representation between the two libraries reveal the differential expression of tick proteins collected from different hosts, and a preliminary description of the I. holocyclus tick salivary gland transcriptome is provided. Expand
Tick paralysis in Australia caused by Ixodes holocyclus Neumann
TLDR
This review focuses on tick paralysis, the role of the Australian paralysis tick Ixodes holocyclus, and therole of toxin molecules from this species in causing paralysis in the host. Expand
Distributions of the paralysis ticks Ixodes cornuatus and Ixodes holocyclus in south-eastern Australia.
TLDR
I holocyclus and I cornuatus have more restricted distributions than current collections suggest and therefore may have the possibility to extend their geographical ranges in the future. Expand
Putative RNA viral sequences detected in an Ixodes scapularis-derived cell line.
TLDR
Characterise putative RNA viral sequences detected in the culture supernatant of one of the most frequently used tick cell lines, ISE6, which was derived from embryos of the blacklegged tick Ixodes scapularis, and identified a member of the family Iflaviridae, which is an arthropod-infecting virus group. Expand
ICTV Virus Taxonomy Profile: Iflaviridae
TLDR
The most common route of infection for iflaviruses is the ingestion of virus-contaminated food sources, and the host range has not been examined for most members. Expand
A novel insect-specific flavivirus replicates only in Aedes-derived cells and persists at high prevalence in wild Aedes vigilax populations in Sydney, Australia.
TLDR
Investigation of the diversity and prevalence of ISFs in Australian mosquitoes, samples from various regions were screened for flaviviruses by ELISA and RT-PCR and revealed PaRV had persisted in A. vigilax populations in Sydney, with 88% of pools positive. Expand
A New Species of Mesonivirus from the Northern Territory, Australia
TLDR
The evolutionary distance between CASV and two of its closest relatives, Cavally and Hana viruses, along with its isolation from a different genus of mosquitoes captured on a separate continent indicate that CASV is a new species. Expand
Bacterial Profiling Reveals Novel “Ca. Neoehrlichia”, Ehrlichia, and Anaplasma Species in Australian Human-Biting Ticks
TLDR
The microbial communities harboured by human-biting ticks from across Australia to identify bacteria that may contribute to Lyme disease-like illness in human patients remains elusive, and phylogenetic analysis of novel “Ca. Neoehrlichia”, Anaplasma and EHRlichia based on 1,265 bp 16S rRNA gene sequences suggests that these are new species. Expand
A novel virus isolated from the aphid Brevicoryne brassicae with similarity to Hymenoptera picorna-like viruses.
  • E. Ryabov
  • Biology, Medicine
  • The Journal of general virology
  • 2007
TLDR
A novel virus, Brevicoryne brassicae virus (BrBV), has been identified in the cabbage aphid using a method based on the random amplification of encapsidated RNA and possesses consensus sequences of the helicase, cysteine protease and RNA-dependent RNA polymerase similar to those of iflaviruses and other picorna-like viruses. Expand
Is there a Lyme-like disease in Australia? Summary of the findings to date
TLDR
The evidence to date as to whether these illnesses in Australia are caused by a Borrelia species, another tick borne pathogen or are due to a novel or unrelated aetiology is summarised in this review. Expand
...
1
2
3
4
...