Discovery of a novel human picornavirus in a stool sample from a pediatric patient presenting with fever of unknown origin.

@article{Jones2007DiscoveryOA,
  title={Discovery of a novel human picornavirus in a stool sample from a pediatric patient presenting with fever of unknown origin.},
  author={Morris S. Jones and Vladimir V. Lukashov and Robert D. Ganac and David P. Schnurr},
  journal={Journal of clinical microbiology},
  year={2007},
  volume={45 7},
  pages={2144-50}
}
Fever of unknown origin (FUO) is a serious problem in the United States. An unidentified agent was cultured from the stool of an infant who presented with FUO. This virus showed growth in HFDK cells and suckling mice. Using DNase sequence-independent single-primer amplification, we identified several nucleotide sequences with a high homology to Theiler's murine encephalomyelitis virus. Nearly full-length viral genome sequencing and phylogenetic analysis demonstrate that this virus is a member… CONTINUE READING