Discovery of a novel glucose metabolism in cancer: The role of endoplasmic reticulum beyond glycolysis and pentose phosphate shunt.

@article{Marini2016DiscoveryOA,
  title={Discovery of a novel glucose metabolism in cancer: The role of endoplasmic reticulum beyond glycolysis and pentose phosphate shunt.},
  author={Cecilia Marini and Silvia Ravera and Ambra Buschiazzo and Giovanna Bianchi and Anna Maria Orengo and Silvia Bruno and Gianluca Bottoni and Laura Emionite and Fabio Pastorino and Elena Monteverde and Lucia Garaboldi and Roberto Martella and Barbara Salani and Davide Maggi and Mirco Ponzoni and Franco Fais and Lizzia Raffaghello and Gianmario Sambuceti},
  journal={Scientific reports},
  year={2016},
  volume={6},
  pages={25092}
}
Cancer metabolism is characterized by an accelerated glycolytic rate facing reduced activity of oxidative phosphorylation. This "Warburg effect" represents a standard to diagnose and monitor tumor aggressiveness with (18)F-fluorodeoxyglucose whose uptake is currently regarded as an accurate index of total glucose consumption. Studying cancer metabolic response to respiratory chain inhibition by metformin, we repeatedly observed a reduction of tracer uptake facing a marked increase in glucose… CONTINUE READING