Discovery of a novel class of highly conserved vaccine antigens using genomic scale antigenic fingerprinting of pneumococcus with human antibodies

@article{Giefing2008DiscoveryOA,
  title={Discovery of a novel class of highly conserved vaccine antigens using genomic scale antigenic fingerprinting of pneumococcus with human antibodies},
  author={Carmen Giefing and Andreas L. Meinke and Markus Hanner and Tam{\'a}s Z Henics and Duc Bui Minh and Dieter Gelbmann and Urban Lundberg and Beatrice M. Senn and Michael Schunn and Andr{\'e} Habel and Birgitta Henriques-Normark and {\AA}ke {\"O}rtqvist and Mats Kalin and Alexander von Gabain and Eszter Nagy},
  journal={The Journal of Experimental Medicine},
  year={2008},
  volume={205},
  pages={117 - 131}
}
Pneumococcus is one of the most important human pathogens that causes life-threatening invasive diseases, especially at the extremities of age. Capsular polysaccharides (CPSs) are known to induce protective antibodies; however, it is not feasible to develop CPS-based vaccines that cover all of the 90 disease-causing serotypes. We applied a genomic approach and described the antibody repertoire for pneumococcal proteins using display libraries expressing 15-150 amino acid fragments of the… CONTINUE READING
Highly Influential
This paper has highly influenced 11 other papers. REVIEW HIGHLY INFLUENTIAL CITATIONS

Citations

Publications citing this paper.
Showing 1-10 of 82 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 50 references

Development of a vaccine against invasive pneumococcal disease based on combinations of virulence proteins of Streptococcus pneumoniae

  • M. A. Barocchi, S. Censini
  • Infect . Immun .
  • 2007

Eff ect of immunization with pneumolysin on survival time of mice challenged with Streptococcus pneumoniae

  • A. D. Ogunniyi, M. Grabowicz, J. Cook, J. C. Paton
  • Infect . Immun .
  • 2007

Similar Papers

Loading similar papers…