Discovery of (R)-1-[2-hydroxy-3-(4-hydroxy-phenyl)-propyl]-4-(4-methyl-benzyl)-piperidin-4-ol: a novel NR1/2B subtype selective NMDA receptor antagonist.

@article{Pinard2001DiscoveryO,
  title={Discovery of (R)-1-[2-hydroxy-3-(4-hydroxy-phenyl)-propyl]-4-(4-methyl-benzyl)-piperidin-4-ol: a novel NR1/2B subtype selective NMDA receptor antagonist.},
  author={Emmanuel Pinard and Alexander I. Alanine and Anne Bourson and Bernd Buettelmann and Ramanjit Gill and M Heitz and Georg Jaeschke and Vincent Mutel and Gerhard Trube and Ren{\'e} Wyler},
  journal={Bioorganic & medicinal chemistry letters},
  year={2001},
  volume={11 16},
  pages={2173-6}
}
Starting from Ro-25-6981 as a lead compound, highly potent and selective NR1/2B subtype selective NMDA receptor antagonists, with low activity at alpha(1) adrenergic receptors were developed.