Discovery of a novel Mycobacterium tuberculosis lineage that is a major cause of tuberculosis in Rio de Janeiro, Brazil.

@article{Lazzarini2007DiscoveryOA,
  title={Discovery of a novel Mycobacterium tuberculosis lineage that is a major cause of tuberculosis in Rio de Janeiro, Brazil.},
  author={Luiz Claudio de Oliveira Lazzarini and Richard C. Huard and Neio L F Boechat and Harrison Magdinier Gomes and Maran{\'i}bia Aparecida Cardoso Oelemann and Natalia Kurepina and Elena Shashkina and Fernanda Carvalho de Queiroz Mello and Andrea L Gibson and Milena J Virginio and Ana Grazia Marsico and W. Ray Butler and Barry Kreiswirth and Philip Noel Suffys and Jos{\'e} Roberto Lapa e Silva and John K. L. Ho},
  journal={Journal of clinical microbiology},
  year={2007},
  volume={45 12},
  pages={3891-902}
}
The current study evaluated Mycobacterium tuberculosis isolates from Rio de Janeiro, Brazil, for genomic deletions. One locus in our panel of PCR targets failed to amplify in approximately 30% of strains. A single novel long sequence polymorphism (>26.3 kb) was characterized and designated RD(Rio). Homologous recombination between two similar protein-coding genes is proposed as the mechanism for deleting or modifying 10 genes, including two potentially immunogenic PPE proteins. The flanking… CONTINUE READING

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