Discovery of a new peptide natural product by Streptomyces coelicolor genome mining.

  title={Discovery of a new peptide natural product by Streptomyces coelicolor genome mining.},
  author={Sylvie Lautru and Robert J. Deeth and Lianne M Bailey and Gregory L Challis},
  journal={Nature chemical biology},
  volume={1 5},
Analyses of microbial genome sequences reveal numerous examples of gene clusters encoding proteins typically involved in complex natural product biosynthesis but not associated with the production of known natural products. In Streptomyces coelicolor M145 there are several gene clusters encoding new nonribosomal peptide synthetase (NRPS) systems not associated with known metabolites. Application of structure-based models for substrate recognition by NRPS adenylation domains predicts the amino… CONTINUE READING
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