Discovery of a new peptide natural product by Streptomyces coelicolor genome mining.

@article{Lautru2005DiscoveryOA,
  title={Discovery of a new peptide natural product by Streptomyces coelicolor genome mining.},
  author={Sylvie Lautru and Robert J. Deeth and Lianne M Bailey and Gregory L Challis},
  journal={Nature chemical biology},
  year={2005},
  volume={1 5},
  pages={265-9}
}
Analyses of microbial genome sequences reveal numerous examples of gene clusters encoding proteins typically involved in complex natural product biosynthesis but not associated with the production of known natural products. In Streptomyces coelicolor M145 there are several gene clusters encoding new nonribosomal peptide synthetase (NRPS) systems not associated with known metabolites. Application of structure-based models for substrate recognition by NRPS adenylation domains predicts the amino… CONTINUE READING
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evidence for an iterative bacterial type I polyketide synthase and for module skipping in nonribosomal peptide biosynthesis

  • Wenzel, S. C. et al. Antibiotics from gliding bacteria, Part 101. Structure, biosynthesis of myxochromides S1–3 in Stigmatella aurantiaca
  • ChemBioChem 6, 375–385
  • 2005

Red-mediated genetic manipulation of antibiotic-producing Streptomyces

  • B Gust
  • Adv. Appl. Microbiol
  • 2004

l Redmediated genetic manipulation of antibioticproducing Streptomyces

  • B. Gust
  • Adv . Appl . Microbiol .
  • 2004

Complete genome sequence and comparative analysis of the industrial microorganism Streptomyces avermitilis

  • H. Ikeda
  • Nat . Biotechnol .
  • 2003

Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2)

  • Bentley, S.D
  • Nature 417,
  • 2002
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