Discovery of a TNF-α Antagonist Using Chondroitin Sulfate Microarrays

  title={Discovery of a TNF-α Antagonist Using Chondroitin Sulfate Microarrays},
  author={S. E. Tully and M. Rawat and L. Hsieh-Wilson},
  journal={Journal of the American Chemical Society},
  • S. E. Tully, M. Rawat, L. Hsieh-Wilson
  • Published 2006
  • Chemistry
  • Journal of the American Chemical Society
  • We report the first example of synthetic chondroitin sulfate (CS) microarrays to rapidly identify glycosaminoglycan−protein interactions and probe the specificity of proteins for distinct sulfation sequences. Using the microarrays, we identify a novel interaction between CS and TNF-α, a proinflammatory cytokine involved in rheumatoid arthritis, Crohn's disease, and psoriasis. Moreover, we demonstrate that CS-E tetrasaccharides and polysaccharides enriched in the CS-E sulfation motif can inhibit… CONTINUE READING
    90 Citations
    The synthesis and biological evaluation of chondroitin sulfate E glycodendrimers.
    • S. Yang, H. Zhang, +5 authors Yinghong Wang
    • Chemistry, Medicine
    • Future medicinal chemistry
    • 2019
    • 2
    Discovery of a Small-Molecule Modulator of Glycosaminoglycan Sulfation.
    • 10
    • PDF
    End-functionalized glycopolymers as mimetics of chondroitin sulfate proteoglycans.
    • 65
    • PDF
    Microarray method for the rapid detection of glycosaminoglycan-protein interactions.
    • 6
    • PDF
    Research and Application of Chondroitin Sulfate/Dermatan Sulfate-Degrading Enzymes
    • PDF
    Anti-arthritic activity of synthesized chondroitin sulfate E hexasaccharide.
    • 4
    • Highly Influenced