Discovery of a Novel Amino Lipid That Improves Lipid Nanoparticle Performance through Specific Interactions with mRNA

@article{Cornebise2021DiscoveryOA,
  title={Discovery of a Novel Amino Lipid That Improves Lipid Nanoparticle Performance through Specific Interactions with mRNA},
  author={Mark Cornebise and Elisabeth Narayanan and Yan Xia and Edward Acosta and Lei Ci and Hillary Koch and Jaclyn Milton and Staci Sabnis and Timothy Salerno and Kerry E. Benenato},
  journal={Advanced Functional Materials},
  year={2021},
  volume={32}
}
Lipid nanoparticles (LNPs) are capable of delivering messenger ribonucleic acid (mRNA) efficiently and systemically as a result of both particle composition and architecture. The particle architecture is determined by how the various components interact with one another to establish a stable equilibrium through self‐assembly. The Coulombic attraction between the anionic oligonucleotide cargo and the ionizable amino lipid within the encapsulation media contributes to the coalescence of the… 

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