Discovery of a Cytokine and Its Receptor by Functional Screening of the Extracellular Proteome

@article{Lin2008DiscoveryOA,
  title={Discovery of a Cytokine and Its Receptor by Functional Screening of the Extracellular Proteome},
  author={Haishan Lin and Ernestine Lee and Kevin Hestir and Cindy Leo and Minmei Huang and Elizabeth Bosch and Robert F. Halenbeck and Ge Wu and Aileen J Zhou and Dirk Behrens and Diane L Hollenbaugh and Thomas Linnemann and Minmin Qin and Justin Jong-Leong Wong and Keting Emeryville Chu and Stephen. Doberstein and Lewis T. Williams},
  journal={Science},
  year={2008},
  volume={320},
  pages={807 - 811}
}
To understand the system of secreted proteins and receptors involved in cell-cell signaling, we produced a comprehensive set of recombinant secreted proteins and the extracellular domains of transmembrane proteins, which constitute most of the protein components of the extracellular space. Each protein was tested in a suite of assays that measured metabolic, growth, or transcriptional responses in diverse cell types. The pattern of responses across assays was analyzed for the degree of… 
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