Discovery of a Class of Endogenous Mammalian Lipids with Anti-Diabetic and Anti-inflammatory Effects

@article{Yore2014DiscoveryOA,
  title={Discovery of a Class of Endogenous Mammalian Lipids with Anti-Diabetic and Anti-inflammatory Effects},
  author={Mark M. Yore and Ismail Syed and Pedro Manoel Mendes Moraes-Vieira and Tejia Zhang and Mark A. Herman and Edwin A. Homan and Rajesh T. Patel and Jennifer G. Lee and Shili Chen and Odile D. Peroni and Abha S. Dhaneshwar and Ann Hammarstedt and Ulf Smith and Timothy E McGraw and Alan Saghatelian and Barbara B. Kahn},
  journal={Cell},
  year={2014},
  volume={159},
  pages={318-332}
}
Increased adipose tissue lipogenesis is associated with enhanced insulin sensitivity. Mice overexpressing the Glut4 glucose transporter in adipocytes have elevated lipogenesis and increased glucose tolerance despite being obese with elevated circulating fatty acids. Lipidomic analysis of adipose tissue revealed the existence of branched fatty acid esters of hydroxy fatty acids (FAHFAs) that were elevated 16- to 18-fold in these mice. FAHFA isomers differ by the branched ester position on the… CONTINUE READING
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