Discovery of a 3-amino-6-phenyl-pyridazine derivative as a new synthetic antineuroinflammatory compound.

@article{Mirzoeva2002DiscoveryOA,
  title={Discovery of a 3-amino-6-phenyl-pyridazine derivative as a new synthetic antineuroinflammatory compound.},
  author={Salida Mirzoeva and Anu R. Sawkar and Magdalena Zasadzki and Ling Guo and Anastasia V. Velentza and Vincent Dunlap and Jean-Jacques Bourguignon and Helena Ramstrom and Jacques Haiech and Linda J. Van Eldik and D Martin Watterson},
  journal={Journal of medicinal chemistry},
  year={2002},
  volume={45 3},
  pages={563-6}
}
Excessive glial activation, with overproduction of cytokines and oxidative stress products, is detrimental and a hallmark of neurodegenerative disease pathology. Suppression of glial activation is a potential therapeutic approach, and protein kinases are targets of some antiinflammatory drugs. To address an unmet need for selective inhibitors of glial activation, we developed a novel 3-amino-6-phenylpyridazine derivative that selectively blocks increased IL-1 beta, iNOS, and NO production by… CONTINUE READING

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