Discovery of YopE Inhibitors by Pharmacophore-Based Virtual Screening and Docking

Abstract

Gram-negative bacteria Yersinia secrete virulence factors that invade eukaryotic cells via type III secretion system. One particular virulence member, Yersinia outer protein E (YopE), targets Rho family of small GTPases by mimicking regulator GAP protein activity, and its secretion mainly induces cytoskeletal disruption and depolymerization of actin stress… (More)
DOI: 10.1155/2013/640518

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Cite this paper

@inproceedings{Ozbuyukkaya2013DiscoveryOY, title={Discovery of YopE Inhibitors by Pharmacophore-Based Virtual Screening and Docking}, author={Gizem Ozbuyukkaya and Elif Ozkirimli Olmez and Kutlu Ozergin Ulgen}, booktitle={ISRN bioinformatics}, year={2013} }