Discovery of SMAD4 promoters, transcription factor binding sites and deletions in juvenile polyposis patients

@inproceedings{Calva2011DiscoveryOS,
  title={Discovery of SMAD4 promoters, transcription factor binding sites and deletions in juvenile polyposis patients},
  author={Daniel Calva and Fadi S. Dahdaleh and George W. Woodfield and Ronald J. Weigel and Jennifer C. Carr and Sathivel Chinnathambi and James R. Howe},
  booktitle={Nucleic acids research},
  year={2011}
}
Inactivation of SMAD4 has been linked to several cancers and germline mutations cause juvenile polyposis (JP). We set out to identify the promoter(s) of SMAD4, evaluate their activity in cell lines and define possible transcription factor binding sites (TFBS). 5'-rapid amplification of cDNA ends (5'-RACE) and computational analyses were used to identify candidate promoters and corresponding TFBS and the activity of each was assessed by luciferase vectors in different cell lines. TFBS were… CONTINUE READING
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