Discovery of S-217622, a Non-Covalent Oral SARS-CoV-2 3CL Protease Inhibitor Clinical Candidate for Treating COVID-19

  title={Discovery of S-217622, a Non-Covalent Oral SARS-CoV-2 3CL Protease Inhibitor Clinical Candidate for Treating COVID-19},
  author={Yuto Unoh and Shotaro Uehara and Kenji S Nakahara and Haruaki Nobori and Yukiko Yamatsu and Shiho Yamamoto and Yuki Maruyama and Yoshiyuki Taoda and Koji Kasamatsu and Takahiro Suto and Kensuke Kouki and Atsufumi Nakahashi and Shotaro Kawashima and Takao Sanaki and Shinsuke Toba and Kentaro Uemura and Tohru Mizutare and Shigeru Ando and Michihito Sasaki and Yasuko Orba and Hirofumi Sawa and Akihiko Sato and Takafumi Sato and Teruhisa Kato and Yuki Tachibana},
The coronavirus disease 2019 (COVID-19) pandemic, caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has resulted in millions of deaths and threatens public health and safety. Despite the rapid global spread of COVID-19 vaccines, effective oral antiviral drugs are urgently needed. Here, we describe the discovery of S-217622, the first oral non-covalent, non-peptidic SARS-CoV-2 3CL protease inhibitor clinical candidate. S-217622 was discovered via virtual screening followed… 

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