Discovery of (R)-4-cyclopropyl-7,8-difluoro-5-(4-(trifluoromethyl)phenylsulfonyl)-4,5-dihydro-1H-pyrazolo[4,3-c]quinoline (ELND006) and (R)-4-cyclopropyl-8-fluoro-5-(6-(trifluoromethyl)pyridin-3-ylsulfonyl)-4,5-dihydro-2H-pyrazolo[4,3-c]quinoline (ELND007): metabolically stable γ-secretase Inhibitors that selectively inhibit the production of amyloid-β over Notch.

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@article{Probst2013DiscoveryO, title={Discovery of (R)-4-cyclopropyl-7,8-difluoro-5-(4-(trifluoromethyl)phenylsulfonyl)-4,5-dihydro-1H-pyrazolo[4,3-c]quinoline (ELND006) and (R)-4-cyclopropyl-8-fluoro-5-(6-(trifluoromethyl)pyridin-3-ylsulfonyl)-4,5-dihydro-2H-pyrazolo[4,3-c]quinoline (ELND007): metabolically stable γ-secretase Inhibitors that selectively inhibit the production of amyloid-β over Notch.}, author={G. Duane Probst and Danielle L Aubele and Simeon G Bowers and Darren B Dressen and Albert William Garofalo and Roy K. Hom and Andrei William Konradi and Jennifer L Marugg and Matthew N Mattson and Martin Neitzel and Chris M Semko and Hing Leung Sham and Jenifer L Smith and Minghua Sun and Anh P Truong and Xiaocong Michael Ye and Ying-zi Xu and Michael S Dappen and Jacek Jerzy Jagodzinski and Pamela S Keim and Brian Peterson and Lee H Latimer and David A Quincy and Jing Wu and Erich G Goldbach and Daniel K. Ness and Kevin Quinn and J Sauer and Karina L. Wong and Hong-bin Zhang and Wes Zmolek and Elizabeth F. Brigham and Dora Kholodenko and Kang Hu and Grace T Kwong and Michael Lee and Anna Liao and Ruth N Motter and Patricia Sacayon and Pamela Santiago and Christopher Willits and Fr{\'e}d{\'e}rique Bard and Michael P. Bova and Susanna S Hemphill and Lam M. Nguyen and Lany Ruslim and Kevin Tanaka and Pearl Tanaka and William Wallace and T . A . Yednock and Guriqbal S. Basi}, journal={Journal of medicinal chemistry}, year={2013}, volume={56 13}, pages={5261-74} }