Discovery of Potent Dual PPARα Agonists/CB1 Ligands.

Abstract

This letter describes the synthesis and in vitro and in vivo evaluation of dual ligands targeting the cannabinoid and peroxisome proliferator-activated receptors (PPAR). These compounds were obtained from fusing the pharmacophores of fibrates and the diarylpyrazole rimonabant, a cannabinoid receptor antagonist. They are the first examples of dual compounds… (More)
DOI: 10.1021/ml200091q

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