Discovery of Novel Mycobacterial DNA Gyrase B Inhibitors: In Silico and In Vitro Biological Evaluation.

Abstract

DNA gyrase of Mycobacterium tuberculosis (MTB) is a type II topoisomerase that ensures the regulation of DNA topology and has been genetically demonstrated to be a bactericidal drug target. Availability of crystal structure of M. smegmatics GyrB in complex with one of the aminopyrazinamides facilitated us to employ structure-based virtual screening approach… (More)
DOI: 10.1002/minf.201400058

Topics

16 Figures and Tables

Cite this paper

@article{Saxena2014DiscoveryON, title={Discovery of Novel Mycobacterial DNA Gyrase B Inhibitors: In Silico and In Vitro Biological Evaluation.}, author={S. Saxena and Janupally Renuka and Perumal Yogeeswari and Dharmarajan Sriram}, journal={Molecular informatics}, year={2014}, volume={33 9}, pages={597-609} }