Discovery of Novel Antifungal (1,3)-β-d-Glucan Synthase Inhibitors

@article{Onishi2000DiscoveryON,
  title={Discovery of Novel Antifungal (1,3)-$\beta$-d-Glucan Synthase Inhibitors},
  author={J. C. Onishi and Maria S. Meinz and J R Thompson and James E. Curotto and Sarah Dreikorn and Mark J Rosenbach and Cameron M. Douglas and George K. Abruzzo and Amy M. Flattery and Lingsheng Kong and Angeles Cabello and Francisca Vicente and Fernando Peláez and M T D{\'i}ez and Isabella Martin and G Bills and Robert A. Giacobbe and Anne W. Dombrowski and Robert E. Schwartz and Sandra A. Morris and Guy H. Harris and A. Tsipouras and Kenneth E. Wilson and Myra Berman Kurtz},
  journal={Antimicrobial Agents and Chemotherapy},
  year={2000},
  volume={44},
  pages={368 - 377}
}
ABSTRACT The increasing incidence of life-threatening fungal infections has driven the search for new, broad-spectrum fungicidal agents that can be used for treatment and prophylaxis in immunocompromised patients. Natural-product inhibitors of cell wall (1,3)-β-d-glucan synthase such as lipopeptide pneumocandins and echinocandins as well as the glycolipid papulacandins have been evaluated as potential therapeutics for the last two decades. As a result, MK-0991 (caspofungin acetate; Cancidas), a… 
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