Discovery of GnIH and Its Role in Hypothyroidism-Induced Delayed Puberty

  title={Discovery of GnIH and Its Role in Hypothyroidism-Induced Delayed Puberty},
  author={Kazuyoshi Tsutsui and You Lee Son and Mika Kiyohara and Ichiro Miyata},
It is known that hypothyroidism delays puberty in mammals. Interaction between the hypothalamo-pituitary-thyroid (HPT) and hypothalamo-pituitary-gonadal (HPG) axes may be important processes in delayed puberty. Gonadotropin-inhibitory hormone (GnIH) is a newly discovered hypothalamic neuropeptide that inhibits gonadotropin synthesis and release in quail. It now appears that GnIH is conserved across various mammals and primates, including humans, and inhibits reproduction. We have further… 

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