Discovery of GPX4 inhibitory peptides from random peptide T7 phage display and subsequent structural analysis.

@article{Sakamoto2017DiscoveryOG,
  title={Discovery of GPX4 inhibitory peptides from random peptide T7 phage display and subsequent structural analysis.},
  author={Kotaro Sakamoto and Satoshi Sogabe and Yusuke Kamada and Shin-ichi Matsumoto and Akito Kadotani and Junichi Sakamoto and Akiyoshi Tani},
  journal={Biochemical and biophysical research communications},
  year={2017},
  volume={482 2},
  pages={
          195-201
        }
}
The phospholipid hydroperoxidase glutathione peroxidase (GPX4) is an enzyme that reduces lipid hydroperoxides in lipid membranes. Recently, GPX4 has been investigated as a target molecule that induces iron-dependent cell death (ferroptosis) selectively in cancer cells that express mutant Ras. GPX4 inhibitors have the potential to become novel anti-cancer drugs. However, there are no druggable pockets for conventional small molecules on the molecular surface of GPX4. To generate GPX4 inhibitors… CONTINUE READING