Discovery of Bioactive Natural Products for the Treatment of Acute Respiratory Infections - An Integrated Approach.

  title={Discovery of Bioactive Natural Products for the Treatment of Acute Respiratory Infections - An Integrated Approach.},
  author={Ulrike Grienke and Christina E. Mair and Johannes Kirchmair and Michaela Schmidtke and Judith M. Rollinger},
  journal={Planta medica},
  volume={84 9-10},
In this work, an integrated approach for the identification of new antiviral agents from natural sources for the treatment of acute respiratory infections is presented. The approach comprises (i) the selection of starting material based on traditional knowledge, (ii) phenotypic screening of extracts for antiviral activity, and (iii) the implementation of in silico predictions to identify antiviral compounds and derive the molecular mechanism underlying their biological activity. A variety of… 

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