Discovery of 4-azaindoles as novel inhibitors of c-Met kinase.

@article{Porter2009DiscoveryO4,
  title={Discovery of 4-azaindoles as novel inhibitors of c-Met kinase.},
  author={John R Porter and Simon Lumb and Richard J Franklin and Jose M Gascon-Simorte and Mark D Calmiano and Kelly Le Riche and B{\'e}n{\'e}dicte I L F Lallemand and Jean Keyaerts and Helen Edwards and Alison Maloney and Jean Delgado and Lloyd M King and Anne Foley and Fabien Lecomte and James Reuberson and Christoph Meier and Mark J Batchelor},
  journal={Bioorganic & medicinal chemistry letters},
  year={2009},
  volume={19 10},
  pages={2780-4}
}
A series of 4-azaindole inhibitors of c-Met kinase is described. The postulated binding mode was confirmed by an X-ray crystal structure and series optimisation was performed on the basis of this structure. Future directions for series development are discussed.