Discovery of 4-amino-3-arylsulfoquinolines, a novel non-acetylenic chemotype of metabotropic glutamate 5 (mGlu5) receptor negative allosteric modulators.

Abstract

Negative allosteric modulators of metabotropic glutamate receptor 5 (mGlu5) showed efficacy in a number of animal models of different CNS diseases including anxiety and depression. Virtually all of the compounds which reached the clinic belong to the same chemotype having an acetylenic linker that connects (hetero)cyclic moieties. Searching for new… (More)
DOI: 10.1016/j.ejmech.2017.03.071

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@article{Galambos2017DiscoveryO4, title={Discovery of 4-amino-3-arylsulfoquinolines, a novel non-acetylenic chemotype of metabotropic glutamate 5 (mGlu5) receptor negative allosteric modulators.}, author={J{\'a}nos Galambos and Attila Bielik and G{\'a}bor W{\'a}gner and Gy{\"{o}rgy Dom{\'a}ny and J{\'a}nos K{\'o}ti and Zolt{\'a}n B{\'e}ni and {\'A}ron Szigetv{\'a}ri and Zsuzsanna S{\'a}nta and Zolt{\'a}n Orgov{\'a}n and Amrita Bobok and B{\'e}la Kiss and M{\'o}nika L Mik{\'o}-Bakk and M{\'o}nika Vastag and Katalin S{\'a}ghy and Mikhail Krasavin and Krisztina G{\'a}l and Istv{\'a}n Greiner and Zsolt Szombathelyi and Gy{\"{o}rgy M Keserű}, journal={European journal of medicinal chemistry}, year={2017}, volume={133}, pages={240-254} }