Arresting the Development of Addiction: The Role of β-Arrestin 2 in Drug Abuse.
- Kirsten A Porter-Stransky, David Weinshenker
- The Journal of pharmacology and experimental…
- 2017
Highly Influenced
5 Excerpts
Discovery of β-arrestin-biased dopamine D2 ligands for probing signal transduction pathways essential for antipsychotic efficacy.
- Published 2011 in Proceedings of the National Academy of Sciences…
Abstract
Elucidating the key signal transduction pathways essential for both antipsychotic efficacy and side-effect profiles is essential for developing safer and more effective therapies. Recent work has highlighted noncanonical modes of dopamine D(2) receptor (D(2)R) signaling via β-arrestins as being important for the therapeutic actions of both antipsychotic and… (More)