Discovery and validation of new protein biomarkers for urothelial cancer: a prospective analysis.

@article{Theodorescu2006DiscoveryAV,
  title={Discovery and validation of new protein biomarkers for urothelial cancer: a prospective analysis.},
  author={Dan Theodorescu and Stefan Wittke and Mark Ross and Michael R. Walden and Mark C Conaway and Ingo Just and Harald Mischak and Henry F. Frierson},
  journal={The Lancet. Oncology},
  year={2006},
  volume={7 3},
  pages={230-40}
}
BACKGROUND Non-invasive methods for diagnosis of urothelial carcinoma have reduced specificity in patients with non-malignant genitourinary disease or other disorders. We aimed to use mass spectrometry and bioinformatics to define and validate a cancer-specific proteomic pattern. METHODS We used capillary-electrophoresis-coupled mass spectrometry to obtain polypeptide patterns from urine samples of 46 patients with urothelial carcinoma and 33 healthy volunteers. From signatures of polypeptide… CONTINUE READING

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