Discovery and validation of a serum microRNA signature to characterize oligo- and polymetastatic prostate cancer: not ready for prime time

  title={Discovery and validation of a serum microRNA signature to characterize oligo- and polymetastatic prostate cancer: not ready for prime time},
  author={Bert Dhondt and Elise De Bleser and Tom Claeys and Sarah Buelens and Nicolaas Lumen and Jo Vandesompele and Anneleen Beckers and Val{\'e}rie Fonteyne and Kim Van der Eecken and Aur{\'e}lie De Bruycker and J{\'e}r{\^o}me Paul and Pierre Gramme and Piet Ost},
  journal={World Journal of Urology},
PurposePatients with oligometastatic prostate cancer (PC) may benefit from metastasis-directed therapy (MDT), delaying disease progression and the start of palliative systemic treatment. However, a significant proportion of oligometastatic PC patients progress to polymetastatic PC within a year following MDT, suggesting an underestimation of the metastatic load by current staging modalities. Molecular markers could help to identify true oligometastatic patients eligible for MDT.MethodsPatients… 

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