Discovery and synthesis of new immunosuppressive alkaloids from the stem of Fissistigma oldhamii (Hemsl.) Merr.

@article{Zhang2007DiscoveryAS,
  title={Discovery and synthesis of new immunosuppressive alkaloids from the stem of Fissistigma oldhamii (Hemsl.) Merr.},
  author={Yi-nan Zhang and X Zhong and Zong-Ping Zheng and Xu-dong Hu and Jian-ping Zuo and Lihong Hu},
  journal={Bioorganic & medicinal chemistry},
  year={2007},
  volume={15 2},
  pages={988-96}
}
Three new alkaloids (1-3) and twenty-one known compounds were isolated from the stem of Fissistigma oldhamii (Hemsl.) Merr. which was the ruler herb in an approved Traditional Chinese herbal formula used for treatment of rheumatoid arthritis in China and synthesis of one new immunosuppressive alkaloid was achieved. These compounds, including the crude extracts of this herb, exhibited strong activities in the inhibition of T and B cell proliferation.