Discovery and prioritization of somatic mutations in diffuse large B-cell lymphoma (DLBCL) by whole-exome sequencing.

  title={Discovery and prioritization of somatic mutations in diffuse large B-cell lymphoma (DLBCL) by whole-exome sequencing.},
  author={Jens G. Lohr and Petar Stojanov and Michael Sohn Lawrence and Daniel Auclair and Bjoern Chapuy and Carrie L. Sougnez and Peter Cruz-Gordillo and Birgit Knoechel and Yan W. Asmann and Susan L. Slager and Anne J. Novak and Ahmet Dogan and Stephen M Ansell and Brian K Link and Lihua Zou and Joshua Gould and Gordon Saksena and Nicolas Stransky and Claudia Rangel-Escare{\~n}o and Juan C. Fern{\'a}ndez-L{\'o}pez and Alfredo Hidalgo-Miranda and Jorge Melendez-Zajgla and Enrique Hern{\'a}ndez-Lemus and Angela Schwarz-Cruz y Celis and Iv{\'a}n Imaz-Rosshandler and Akinyemi I Ojesina and Joonil Jung and Chandra Sekhar Pedamallu and Eric S. Lander and Thomas Matthew Habermann and James R. Cerhan and Margaret A Shipp and Gad Getz and Todd R. Golub},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  volume={109 10},
To gain insight into the genomic basis of diffuse large B-cell lymphoma (DLBCL), we performed massively parallel whole-exome sequencing of 55 primary tumor samples from patients with DLBCL and matched normal tissue. We identified recurrent mutations in genes that are well known to be functionally relevant in DLBCL, including MYD88, CARD11, EZH2, and CREBBP. We also identified somatic mutations in genes for which a functional role in DLBCL has not been previously suspected. These genes include… CONTINUE READING
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