Discovery and optimization of potent broad-spectrum arenavirus inhibitors derived from benzimidazole and related heterocycles.

@article{Burgeson2013DiscoveryAO,
  title={Discovery and optimization of potent broad-spectrum arenavirus inhibitors derived from benzimidazole and related heterocycles.},
  author={James R Burgeson and Amy L Moore and Dima N Gharaibeh and Ryan A Larson and Natasha R Cerruti and Sean M Amberg and Dennis E. Hruby and Dongcheng Dai},
  journal={Bioorganic & medicinal chemistry letters},
  year={2013},
  volume={23 3},
  pages={750-6}
}
A series of potent arenavirus inhibitors sharing a benzimidazole core were previously reported by our group. SAR studies were expanded beyond the previous analysis, which involved the attached phenyl rings and methylamino linker portion, to include modifications focused on the benzimidazole core. These changes included the introduction of various substituents to the bicyclic benzimidazole ring system along with alternate core heterocycles. Many of the analogs containing alternate nitrogen-based… CONTINUE READING