Discovery and molecular engineering of sugar-containing natural product biosynthetic pathways in actinomycetes.

@article{Oh2007DiscoveryAM,
  title={Discovery and molecular engineering of sugar-containing natural product biosynthetic pathways in actinomycetes.},
  author={Tae-Jin Oh and Sang Joon Mo and Yeo Joon Yoon and Jae Kyung Sohng},
  journal={Journal of microbiology and biotechnology},
  year={2007},
  volume={17 12},
  pages={1909-21}
}
Significant progress has recently been made concerning the engineering of deoxysugar biosynthesis. The biosynthetic gene clusters of several deoxysugars from various polyketides and aminoglycosides-producing microorganisms have been cloned and studied. This review introduces the biosynthetic pathways of several deoxysugars and the generation of novel hybrid macrolide antibiotics via the coexpression of deoxysugar biosynthetic gene cassettes and the substrateflexible glycosyltransferases in a… CONTINUE READING