Discovery and mode of action of afoxolaner, a new isoxazoline parasiticide for dogs.

  title={Discovery and mode of action of afoxolaner, a new isoxazoline parasiticide for dogs.},
  author={Wesley L Shoop and Eric J. Hartline and Brandon R. Gould and Molly E. Waddell and Richard G McDowell and John B. Kinney and George P. Lahm and Jeffrey K. Long and Ming Xu and Ty R. Wagerle and Gail S. Jones and Robert F. Dietrich and Daniel Andr{\'e}s C{\'o}rdova and Mark E. Schroeder and Daniel F Rhoades and Eric A. Benner and Pat N. Confalone},
  journal={Veterinary parasitology},
  volume={201 3-4},
Afoxolaner is an isoxazoline compound characterized by a good safety profile and extended effectiveness against fleas and ticks on dogs following a single oral administration. In vitro membrane feeding assay data and in vivo pharmacokinetic studies in dogs established an afoxolaner blood concentration of 0.1-0.2 μg/ml to be effective against both fleas (Ctenocephalides felis) and ticks (Dermacentor variabilis). Pharmacokinetic profiles in dogs following a 2.5mg/kg oral dosage demonstrated… CONTINUE READING
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