Discovery and mechanistic study of a small molecule inhibitor for motor protein KIFC1.

Abstract

Centrosome amplification is observed in many human cancers and has been proposed to be a driver of both genetic instability and tumorigenesis. Cancer cells have evolved mechanisms to bundle multiple centrosomes into two spindle poles to avoid multipolar mitosis that can lead to chromosomal segregation defects and eventually cell death. KIFC1, a kinesin-14… (More)
DOI: 10.1021/cb400186w

Topics

Figures and Tables

Sorry, we couldn't extract any figures or tables for this paper.